"This study establishes MTAP-del as a biomarker in bladder cancer. We are now ready for a trial in MTAP-del bladder cancer in combination with other inhibitors of the pathway." --Joaquim Bellmunt, MD, ...

“In breast cancer, MTAP downregulation activates ornithine decarboxylase (ODC) which in turn leads to formation of putrescine which promotes tumor migration, invasion and angiogenesis [15].” “We ...

MTAP encodes methylthioadenosine phosphorylase, an enzyme in the methionine salvage pathway that recycles methylthioadenosine to methionine. The gene resides on chromosome 9p21.3, adjacent to the ...

Insilico Medicine is heading to the clinic with its seventh pipeline candidate discovered and designed using generative artificial intelligence (AI), a treatment for methylthioadenosine phosphorylase ...

Clinical outcomes according to PD-L1 status and age in the prospective international SAUL study of atezolizumab (atezo) for locally advanced or metastatic urothelial carcinoma (UC) or non-UC of the ...

Single cell RNA sequencing of upper tract urothelial carcinoma to reveal significant heterogeneity of the tumor and immune microenvironment.