New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · When they cranked up tau expression in glia throughout the fly brain, glial lipid droplets plummeted by more than 90 percent, and peroxidated lipids accumulated. Similarly, in co-cultures of …
Amelioration of Tau and ApoE4-linked glial lipid ... - ALZFORUM
Nov 29, 2023 · Here, Alexandra Litvinchuk from David Holtzman’s laboratory investigated the effect of the LXR agonist GW3965 as well as overexpression of ABCA1 on tau and apoE4-linked glial lipid …
Regulation of cell distancing in peri-plaque glial nets by ... - ALZFORUM
Jun 5, 2024 · Important features of signaling within the glial nets—e.g., the identity of the Plexin-B1 ligand, how Plexin-B1 activation in astrocytes affects the physiology of microglia—remain to be …
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain ...
Feb 27, 2024 · Further, neuronal but not glial mitochondria became oxidized. This suggests that neurons were indeed the source of the peroxidated lipids and that, by shuttling them to glia, neurons …
Sans Plexin-B1, Glial Net Tightens Around Plaques - ALZFORUM
Jun 1, 2024 · Plexin-B1 expression by astrocytes imposes cell spacing in glial nets. Without Plexin-B1, glia huddle more closely together, and with plaques. The result? Smaller plaques, protected …
MAPT K317N | ALZFORUM
Nov 3, 2025 · Findings This mutation was detected in a woman with a constellation of symptoms suggestive of frontotemporal dementia, progressive supranuclear palsy, and motor neuron disease …
Transcriptomics Paint Astrocytes as Source of Cognitive Resilience
Jul 26, 2024 · Glial cells responded more consistently across regions, and the researchers pegged astrocytes as the lone cell type in which gene expression synced strongly with cognitive resilience. …
Glial lipid droplets resolve ROS during sleep. | ALZFORUM
Feb 27, 2024 · Most previous work on this process focused on disease conditions. However, Haynes and colleagues discovered that glial lipid droplet accumulation occurs as part of a daily rhythm: in …
Astrocyte reactivity influences amyloid-β effects on tau ... - ALZFORUM
Jun 2, 2023 · Glial cell involvement in AD was noted in the earliest observations of Dr. Alzheimer. It is not surprising that a marker of astrocyte activation, GFAP, is elevated in the plasma from patients …
DNL788 - ALZFORUM
These and other studies raised the profile of RIPK1 as a glial target to try to reduce neuroinflammation and cell death across several neurodegenerative diseases (Yuan et al., 2019).