Poly (ADP-ribose) polymerase - Wikipedia
Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. [1] The PARP …
PARP Inhibitors: What They Are, Types & Side Effects
Jan 20, 2025 · PARP inhibitors are a targeted therapy treatment for some forms of cancers that involve changes (mutations) in the BRCA gene. This includes some types of breast, ovarian …
What are PARP inhibitors? - MD Anderson Cancer Center
Apr 3, 2024 · PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) …
List of PARP inhibitors (Poly (ADP-ribose) polymerase inhibitors ...
Apr 14, 2023 · Poly (ADP-ribose) polymerase inhibitors, also called PARP inhibitors, are targeted therapies that are used to treat cancer. PARP is a protein that has a role in cellular growth, …
PARP and PARG inhibitors in cancer treatment - PMC
In this review, Slade provides an overview of the molecular mechanisms and cellular consequences of PARP and PARG inhibition.
PARP inhibitors: Overview and indications - The Jackson Laboratory
PARP (poly ADP-ribose polymerase) are proteins that bind to broken strands of DNA and recruit other proteins to repair damaged DNA. There are multiple pathways (controlled by multiple …
Definition of PARP inhibitor - NCI Dictionary of Cancer Terms
A substance that blocks an enzyme in cells called PARP. PARP helps repair DNA when it becomes damaged. DNA damage may be caused by many things, including exposure to UV …
What Is a PARP Inhibitor and How Does It Work?
Aug 21, 2025 · These medications work by interfering with the function of poly-ADP ribose polymerase (PARP) enzymes, which are proteins naturally found in cells. The goal of PARP …
How Do PARP Inhibitors Work In Cancer? - Dana-Farber Cancer Institute
Jul 21, 2016 · PARP inhibitors are a targeted therapy used to treat certain cancers, including breast, ovarian, pancreatic, and prostate cancer, particularly in patients with BRCA1/2 …
PARP Inhibitors - Susan G. Komen®
Feb 27, 2025 · Poly (ADP-ribose) polymerase (PARP) is an enzyme that helps repair DNA damage. PARP inhibitors are drugs that try to keep cancer cells from repairing damaged tumor …